发明名称 |
PROCESS FOR THE PREPARATION OF A COMPOSITION CONTAINING A FACTOR VIII(AHF) |
摘要 |
<p>There is described a method for producing a preparation having a high content of Factor VIII (AHF), i.e. with a specific activity of at least 1.5 units of Factor VIII/mg protein, immunoglobulin G (IgG) of from 15 to 30 mg/1000 units of Factor VIII and fibrinogen of from 20 to 40 mg/100 units of Factor VIII. The method consists in that a Factor VIII containing plasma fraction is dissolved in a buffer, the solution is purified from undesired proteins by precipitation and is concentrated, the precipitation of undesired proteins being carried out in the presence of sulfated polysaccharide at a pH of from 6 to 7. After separation of the undesired proteins, a Factor VIII concentrate is precipitated, dissolved and processed into stable form. If desired, an antithrombin III-heparin complex or an antithrombin III-heparinoid complex is added to the solution.</p> |
申请公布号 |
EP0127603(B1) |
申请公布日期 |
1989.01.04 |
申请号 |
EP19840890083 |
申请日期 |
1984.05.10 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT FUR CHEMISCH-MEDIZINISCHE PRODUKTE |
发明人 |
LINNAU, YENDRA, DR.;SCHWARZ, OTTO, DR. |
分类号 |
A61K35/14;A61K35/16;A61K38/00;A61K38/43;A61P7/04;C07K14/755;(IPC1-7):A61K35/16;A61K37/02 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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