| 摘要 |
PURPOSE:To obtain a 3,5-di(alpha-methylbenzyl)salicylic acid derivative by simple operation using an inexpensive raw material by reacting salicylic acid and alpha-methylbenzyl halide represented by a specific formula in an org. solvent in the presence of aliphatic sulfonic acid. CONSTITUTION:A 3,5-di(alpha-methylbenzyl)salicylic acid drivative is produced by reacting salicylic acid and alpha-methylbenzyl halide represented by formula (wherein R1 and R2 are a hydrogen atom or a 1-4C alkyl group and X is a halogen atom) in an org. solvent in the presence of aliphatic sulfonic acid. Salicylic aid said to be low in reactivity in electrophilic reaction because of an aromatic compd. having a carboxyl group originally being electron drawing group is used as a raw material to produce the objective 3,5-di(alpha- methylbenzyl)salicylic acid under gentle condition and, further, aliphatic sulfonic acid used in reaction is easily separated and recovered after the completion of reaction to be capable of being reutilized. |
