发明名称 |
ADHESIN-ENTEROTOXIN CHIMERA BASED IMMUONGENIC COMPOSITION AGAINST ENTEROTOXIGENIC ESCHERICHIA COLI |
摘要 |
The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response. |
申请公布号 |
CA2635409(C) |
申请公布日期 |
2016.06.28 |
申请号 |
CA20072635409 |
申请日期 |
2007.01.11 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY;THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
SAVARINO, STEPHEN J.;HOLMES, RANDALL K.;JOBLING, MICHAEL G. |
分类号 |
A61K39/108 |
主分类号 |
A61K39/108 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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