RECOMBINANT ADENOVIRUS EXPRESSING A GENE ENCODING STREPTOLYSIN O PROTEIN AND ANTI-CANCER COMPOSITION COMPRISING SAME

摘要

A recombinant adenovirus expressing a streptolysin O (SLO) protein comprising a SLO gene; a promoter operably linked to the SLO gene; a polyadenylation signal sequence; and an adenovirus genome lacking E1 gene effectively kills a cancer cell by expressing a pore-forming toxin, SLO protein, and, therefore, is useful for the suicide cancer gene therapy.