Use of indolone compounds to treat malaria and inhibit the growth of the (non)resistant strains of Plasmodium falciparum, preferably one of the resistant strain to chloroquine

摘要

Use of indolone compounds (I) or their salts for the manufacture of a medicament to treat malaria, is claimed. Use of indolone compounds of formula (I) or their salts for the manufacture of a medicament to treat malaria, is claimed. X 1-X 4C, N or -NO; either R 11-6C alkyl (optionally substituted and unsaturated), cycloalkyl, aryl, arylalkyl or heterocycle (all optionally substituted), -CN, -COOR 3, -COR 3, -CONR 3R 4, -CF 3, -OCF 3, -OR 3, -OSO 2R 3, -SO 3H, -SO 3Na, -NO 2, -NR 3R 4, -NHCOR 3, -SR 3, -SOR 3, -SO 2R 3, -SO 2NR 3R 4, -SO 2CF 3, H or halo (which is F, Cl, Br or I); or R 1R 1cycle, which is -O(CH 2) mO-, -HN-CH=N- or -HN-CH=CH-NH-; R 3, R 41-6C alkyl (optionally unsaturated), cycloalkyl, aryl or arylalkyl (all optionally substituted) or H; and R 21-6C alkyl (optionally substituted and unsaturated), aryl or heterocycle (both optionally substituted), H, -COR 3or -COOR 3; n : 0-4; and m : 1-2. Independent claims are included for: (1) composition comprising at least (I) in association with excipients; and (2) use of (I) in association with at least another antimalarial agent for the preparation of a medicament to the treatment of malaria with a simultaneously, separately or temporarily gradual administration. [Image] ACTIVITY : Antimalarial. MECHANISM OF ACTION : None given.