ANTIBODIES BISPECIFIC TO ERB-B AND THEIR APPLICATION IN TUMOUR TREATMENT

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns medicine, particularly immunotherapy. Invention claims bispecific antibody and its application in tumour treatment. New antibody can link to EGF receptor and includes two antigene-binding sites linking to different epitopes of indicated receptor, thus ensuring higher receptor engagement by antibodies at the same dosage. It allows for higher antibody density on receptor and significant inhibition of tumour growth and/or enhancement of solid tumour or metastasis apoptosis. ^ EFFECT: higher receptor engagement by antibodies at the same dosage. ^ 16 cl, 2 ex