Process for preparing optically active nucleosides from chiral cyclobutanones

摘要

A process is disclosed for the preparation of optically active purine nucleosides, particularly nucleosides of formulae 1 and 2, nucleoside analogs and optically active intermediates of formula 3 which may be used in the preparation of nucleosides of the formula 4 as well as a purine nucleosides and nucleoside analogs. <IMAGE> 1 <IMAGE> 2 <IMAGE> 3 <IMAGE> 4 The process is directed to the preparation of such compounds, including novel such compounds in their respective alpha - and beta -anomeric forms, and the enantiomeric forms of these compounds. These compounds show various levels of anti-viral and/or anti-cancer activity.