| 摘要 |
The present invention relates to a DNA sequence encoding a papillomavirus L1 protein capable of efficiently forming virus-like particles (VLP). In particular, the present invention relates to a DNA sequence encoding an HPV16 L1 protein. Furthermore, the present invention relates to expression plasmids containing said DNA, to host cells transformed by said expression plasmids, to methods for the production of said L1 protein, to the VLP formed by said L1 protein, to antibodies reacting with said protein and said VLP, to diagnostic and pharmaceutical compositions and methods and to a vaccine comprising said VLP.
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