CULTURES OF PERMANENT LINES OF HUMAN PROMYELOCYTE CELLS, THEIR USE FOR SCREENING MOLECULES USEFUL PARTICULARLY IN TREATING LEUKEMIAS

摘要

The invention concerns permanent cell lines characterized in that they consist essentially of human promyelocyte cells characteristic of acute promyelocytic leukemias, these cells being cytogenetically characterized by a translocation t(15;17), capable of indefinite proliferation in a culture medium. It also concerns the use of these cell lines, particularly for screening molecules capable of inducing cell maturation.