| 发明名称 |
Camptothecins Conjugated in Position 7 to Cyclic Peptides as Cytostatic Agents |
| 摘要 |
Compounds of Formula (I) are described in which the R<SUB>1 </SUB>group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alpha<SUB>v</SUB>beta<SUB>3 </SUB>and alpha<SUB>v</SUB>beta<SUB>5 </SUB>and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
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| 申请公布号 |
US2008033003(A1) |
申请公布日期 |
2008.02.07 |
| 申请号 |
US20050596015 |
申请日期 |
2005.05.04 |
| 申请人 |
PISANO CLAUDIO;GIANNINI GIUSEPPE;TINTI MARIA OMELLA;VESCI LOREDANA;ALLOATTI DOMENICO;PENCO SERGIO;DAL POZZO ALMA;MINGHONG NI;DALLAVALLE SABRINA;MERLINI LUCIO;ZUNINO FRANCO |
发明人 |
PISANO CLAUDIO;GIANNINI GIUSEPPE;TINTI MARIA OMELLA;VESCI LOREDANA;ALLOATTI DOMENICO;PENCO SERGIO;DAL POZZO ALMA;MINGHONG NI;DALLAVALLE SABRINA;MERLINI LUCIO;ZUNINO FRANCO |
| 分类号 |
A61K31/436;A61K38/08;A61P31/12;A61P33/00;A61P35/00;A61P35/04;C07K7/64 |
主分类号 |
A61K31/436 |
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