Compositions and Methods to Image and Quantify Inflammation

摘要

Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19F-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of inflammation, thus permitting non-invasive evaluation of inflammation in patients. The present methods provide a tool for assessing inflammation in a wide variety of autoimmune diseases and may have particular utility in intestinal diseases such as Crohn's disease, ulcerative colitis, inflammatory bowel disease, and cardio myositis.

主权项

1. An emulsion useful for labeling leukocytes, comprising:
a 19F-containing molecule; a surfactant; and water, wherein the emulsion has an average particle size between about 10 nanometers and about 500 nanometers.