摘要 |
Purine-nucleoside-5'-carboxylic acids are made by subjecting a purine-nucleoside, in which the 2',3'-cis-oriented hydroxy groups are protected by blocking groups, to oxidation with an excess of potassium permanganate in an alkaline aqueous solution, followed by precipitation of the 5'-carboxylic acid. Subsequently the blocking groups may be split off. |