| 摘要 |
NEW MATERIAL:26,26,26,27,27,27- Hexafluoro -6,19-epidioxy-9,10-secocholesta-5 (10),7-diene-1alpha,3beta,25-triol of formula I. USE:An antitumor agent having differentiation-inducing activity of myelocytic leukemia cell to granulocyte, and exhibiting the effect for a long time. PREPARATION:The compound of formula I can be prepared by the photosensitized oxidation of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol (or corresponding vitamin D3 derivative) under radiation of visible light with a halogen lamp, etc., in a solvent comprising a mixture of benzene, ethanol, etc., in the presence of a photo-sensitizing agent such as rose bengal, etc. and O2 or air.
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