PROCESS FOR PRODUCTION OF POLYPEPTIDE BY REGULATION OF ASSEMBLY

摘要

In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitablyapplied to the preparation of bispecific antibodies.