| 摘要 |
Anti-ulcer and antisecretory 5-substituted-5,10-dihydro-11H-dibenzo (b,e)(1,4) diazepin-11-ones. M3A. Are new compounds of formula:- (where R'=H, alkyl (C1-C4); R2R3=H, halogen; R4 is a monocyclic 5 to 7 membered N-heterocyclic ring opt. interrupted by an O atom or another N atom and opt. substd. by alkyl, hydroxyalkyl, alkoxy, benzyl, methylbenzyl, the heterocyclic ring being bound to the CH2 group by the N atom), including their salts. Oral LD50 in mice is about 1500 mg/kg. Compounds I at 50-100 mg/kg orally in rats give 50-100% inhibition of ulceration after 22 hours, about the same as that of stropine but without its anticholinergic effect. |
