| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new gene coding for a protein relating to aureobacidin sensitivity and obtained from a mold and useful for the diagnosis or treatment of diseases such as mycosis or for the production of a protein for the diagnosis or treatment of mycosis, etc. SOLUTION: This new gene is a gene relating to aureobacidin sensitivity coding for a protein relating to aureobacidin sensitivity and obtained from mold or its functional derivative. It is useful for the genetic diagnosis and treatment of diseases such as mycosis or the genetic engineering production of a protein relating to aureobacidin sensitivity and useful for the diagnosis, treatment, etc., of mycosis. The gene can be produced by extracting a genom DNA from a variant of Aspergillus nidulans resistant to aureobacidin by conventional method, preparing a genom library using the genom DNA, screening the library and confirming the presence of aureobacidin resistance. |
