发明名称 |
DELIVERY OF NUCLEOTIDES INTO ORGANISMS BY ELECTROPORATION |
摘要 |
A method for delivering a nucleotide into an organism includes applying a composition which includes a nucleotide component to epidermis of the organism. The epidermis is electroporated, whereby at least a portion of the composition enters or passes across the epidermis, thereby delivering the nucleotide into the organism. An example of a suitable nucleotide which can be delivered by the method of the invention includes antisense oligodeoxynucleotides for treatment of melanomas.
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申请公布号 |
WO9639531(A1) |
申请公布日期 |
1996.12.12 |
申请号 |
WO1996US08827 |
申请日期 |
1996.06.05 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
ZEWERT, THOMAS, E.;PLIQUETT, UWE;LANGER, ROBERT, S.;WEAVER, JAMES, C. |
分类号 |
A61B5/00;A61K38/38;A61K38/48;A61K41/00;A61K48/00;A61N1/32;C07K14/82;C12N15/87;(IPC1-7):C12N15/87;A61K47/48;A61K31/70 |
主分类号 |
A61B5/00 |
代理机构 |
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地址 |
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