Phospholipase A2 inhibitor, microorganisms producing said inhibitor and processes for its production.

摘要

A compound of the formula (I); <CHEM> wherein R<1>, R<2>, and R<3> are -COOR<4>, -COOR<5>, and -COOR<6>, respectively; R<4>, R<5>, and R<6>, are each hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z are each hydrogen or hydroxyl; the dotted line indicates the presence or absence of a single bond; and wherein W/R<3>, X/R<1>, and/or Z/R<3> may be combined together, to form a lactone, which compound is useful as a phospholipase A2 inhibitor. A process for the production of the compound (I), a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same and pharmaceutical compositions containing the same are also provided.