| 摘要 |
Compounds of formula (1a) or (1b) or (2a) or (2b) and the salts, esters and amides thereof wherein Z is S, SO, SO2 or O; each of R1, R2 and R3 is independently substituted or unsubstituted alkyl (1-10C), substituted or unsubstituted acyl (2-11C), substituted or unsubstituted aryl (6-14C), substituted or unsubstituted arylcarbonyl (7-15C), substituted or unsubstituted arylalkyl (7-15C), substituted or unsubstituted pyridyl wherei n substituents on any alkyl or alkylene moiety are selected from the group consisting of halo, RO, wherein R is H or alkyl (1-6C) and substituents on a ny aryl or pyridyl moiety are selected from the group consisting of halo, RO, where R is H or alkyl (-CN and -CF3); and with the proviso that in formula (1a), the B ring may contain one double bond that is located between positio ns 2 and 3, in formula (1b), the B ring may contain one double bond that can be located between positions 2 and 3 or positions 3 and 4, in formula (2a), the B ring may contain one double bond that can be located between positions 2 and 3 or positions 3 and 4 and in formula (2b), the B ring may contain one or more double bonds that can be located between positions 2 and 3, positions 3 and 4 or positions 4 and 5, are useful as antibacterial agents.
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