摘要 |
Disclosed are dihydropyridinone and piperidinone compounds of formula (I), wherein the substituents are as defined in the specification. The compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments for the treatment or prophylaxis of diabetes, obesity, and dyslipidemia. Example of a compound of formula (I) are: (S)-3-(1H-tetrazol-5-yl)-4-(p-tolyl)-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one (S)-N-(4-methoxyphenyl)-2-oxo-4-(p-tolyl)-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carboxamide (S)-2-(methylsulfonyl)-N-(2-oxo-4-(p-tolyl)-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)acetamide |