发明名称 |
ASSAY FOR PATHOGENICITY OF ANTI-DNA ANTIBODIES |
摘要 |
Assays that are prognostic for patients that will develop nephritis have been developed where patient serum is screened for the presence of anti-dsDNA antibodies that are cross reactive with A and D SnRNP proteins. The assays are based on the use of either peptides containing epitopes bound by the anti-dsDNA antibodies, or the antigens for the antibodies, A and D SnRNP proteins. Therapeutic compositions have also been developed using either antibodies that block the pathogenicity of the anti-dsDNA antibodies, such as the naturally occurring anti-La/SSB and anti-U1RNP antibodies that are cross reactive with the anti-dsDNA or using the peptides or A and D proteins to induce tolerance. |
申请公布号 |
WO9532430(A3) |
申请公布日期 |
1996.03.07 |
申请号 |
WO1995US06412 |
申请日期 |
1995.05.25 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
REICHLIN, MORRIS;KOREN, EUGEN |
分类号 |
A61K38/00;C07K14/47;G01N33/564 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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