摘要 |
A catalytic process for the manufacture of optically active compounds of the formula <IMAGE> I wherein R1 and R2are alkyl, which is optionally interrupted by an O atom in a position other than the alpha -or beta -position, or optionally substituted benzyl, R3 is hydrogen, lower alkyl, optionally substituted benzyl, -CO-R4, -COOR4 or -CONR24, and R4 is lower alkyl or aryl, comprising asymmetrically hydrogenating a compound of the formula <IMAGE> II wherein R1, R2 and R3 have the above significance, in the presence of a complex of an optically active, preferably atropisomeric, diphospine ligand with a metal of Group VIII.
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