| 摘要 |
FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: method involves the preliminary intragastral administration of aqueous solutions of polymers taken from the order including copolymers of N-vinylpyrrolidone and N,N,N,N-triethylmethacryloylhydroxyethyl ammonium iodide of the general formulawhere n = 83-93 mole%; m = 7-17 mole%, MM = (23-120) x 10; complexes of copolymers of N-vinylpyrrolidone and N, N, N, N-triethylmethacryloylhydroxyethyl ammonium iodide with sodium dodecyl sulfate of the general formulawhere n = 83-93 mole%; m = 7-17 mole%; MM = (23-120) x 10; mole ratio m:x = 1:(3.6-4.2); polymeric compositions containing highly dispersed metallic silver stabilized with poly-N-vinylpyrrolidone with MM = (6-40) x 10at the ratio of components, mas. p.p.: poly-N-vinylpyrrolidone 1; silver 0.01-2.33, at the doses 1.5-150and the following administration of a medicinal agent after 15-240 min at the doses that by 10-20-fold less of the usual ones. Method is used for the potentiation of small doses of drugs (soporifics, analgetics, sedatives and narcotics), for toxicity and by-side effects decrease. EFFECT: decreased consumption of drugs for therapeutic effect (by 10-20-fold). |
