PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS

摘要

The present patent application relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R?1, R2 and R3¿ is a non-cyclic acidic group having a pKa value below 8 or a group which is in vivo convertible to such a group; R4, R5 and the other two of the substituents R?1, R2 and R3¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R?3 and R4 or R4 and R5¿ together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R?1, R2, R3, R4 and R5¿ are as defined above; Y is -CO-, -CS-, -SO¿2?-, or -C(=N-R?8¿)-, wherein R8 is hydrogen, alkyl, or cyano; X is -NH-, -CH¿2?-NH-, or -SO2-NH-; Z is NR?6¿, O, -CH=CH-, -C=C-, -N=CH-, or -CH=N-; wherein R6 is hydrogen, or alkyl; R?11, R12, R13, R14 and R15¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, -NHSO¿2?-R?7, -COOR7, -SO¿2N(R7)2, -SO2OR7 and -CO-R7, wherein R7 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl or aralkyl; and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R?11 and R12, R12 and R13, R13 and R14 or R14 and R15¿ together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R?11, R12, R13, R14 and R15¿ are as defined above. The compounds are useful for the treatment of diseases and disorders responsive to the blockage of chloride channels.