RECOMBINANT RSV ANTIGENS

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for eliciting an immune response specific for respiratory syncytial virus (RSV) that are safe and effective as a vaccine for the purpose of preventing RSV infection and/or reducing or preventing RSV disease, including lower respiratory infections (LRIs).SOLUTION: A recombinant respiratory syncytial virus (RSV) antigen comprising a soluble F protein polypeptide comprising an F2 domain and an F1 domain of an RSV F protein polypeptide, where the F protein polypeptide comprises at least one modification that alters glycosylation. Also provided are methods for using the same.SELECTED DRAWING: None