| 摘要 |
<p>The present invention provides gene therapy using recombinant vector delivery systems and particularly adenovirus vectors. The invention specifically provides replication-deficient vectors which are able to replicate specifically in certain abnormal tissues to provide a therapeutic benefit from the vector per se or from heterologous gene products encoded by the vector and distributed throughout the abnormal tissue. Preferably, the tissue is tumor tissue. The invention also provides cell lines for producing recombinant replication-deficient vectors useful for genetic therapy. The invention also provides methods for screening abnormal tissues, and especially tumors, for functions or functional deficiencies that permit vector replication.</p> |
