| 发明名称 | Preparation of bendamustine and its salts | ||
| 摘要 | The present application relate to processes for the preparation of bendamustine and its pharmaceutically acceptable salts. | ||
| 申请公布号 | US9376394(B2) | 申请公布日期 | 2016.06.28 |
| 申请号 | US201013517908 | 申请日期 | 2010.12.22 |
| 申请人 | DR. REDDY'S LABORATORIES LTD.;DR. REDDY'S LABORATORIES, INC. | 发明人 | Kadaboina Rajasekhar;Murki Veerender;Badisa Venkat Rao;Gunda Nageshwar |
| 分类号 | C07D235/16 | 主分类号 | C07D235/16 |
| 代理机构 | Pergament & Cepeda LLP | 代理人 | Pergament & Cepeda LLP ;Cepeda Milagros A.;Pergament Edward D. |
| 主权项 | 1. A process comprising: a) reacting a compound of formula (II): wherein R is a C1-C4 alkyl group, with a 2-haloethanol in the presence of an organic base to give a compound of formula (III); b) reacting the compound of formula (III) with a chlorinating agent to provide a compound of formula (IV); and c) hydrolyzing the compound of formula (IV) to give bendamustine hydrochloride. | ||
| 地址 | Hyderabad IN | ||