PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention concerns pyrrole derivatives of general formula (I) in which R1 is CONH2, CN, COOH, COOAlk, acetyl or imidazolylcarbonyl, R3 is H or halogen, or an alkyl or OH radical, Het is pyridyl, pyridyl N-oxide or thiazolyl, and a) the bond --- is a single bond, R2 is H, halogen, CN, alkyl, alkyloxy, or trihalogenomethyl, R4 is H, and R5 is an OH, OAlk, NH2 or NHCOAlkHal radical or b) the bond --- is a double bond, and R2 is H, halogen, CN, alkyl, alkyloxy, alkylene or trihalogenomethyl, R4 is H, halogen, alkyloxy, or alkylthio optionally substituted by COOH, COOAlk, NH2, alkylamino, dialkylamino the alkyl parts of which can form with the nitrogen atom a heterocyclic compound (4 to 6 chains) and can further comprise another heteroatom selected among N, O or S, or phthalimido, and R5 is H, being understood that R2 cannot be chlorine when simultaneously R4 and R5 are H, and R1 is CN or CONH2, and Het-R3 is pyridyl-3 optionally substituted by F in position -2, or when simultaneously R4 is halogen, R5 is H, and R1 is CN or CONH2 and Het-R3 is pyridyl-3 substituted by CH3, Cl or F in position -2 or R1 is COOAlk or acetyl and Het-R3 is pyridyl-3, the C1-C4 alkyl radicals, acyl and C2-C4 alkylene being linear or branched, if necessary in the form of stereoisomers or their mixtures and/or their salts when they exist. These derivatives are particularly useful for the treatment and prevention of diseases in which are involved viruses of the herpes family and/or cytokines in particular TNFα.