| 摘要 |
The present invention provides compounds of Formula I. Wherein R1, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the compounds.; |
| 主权项 |
1. A compound of the formula below: wherein L is selected from: —CH2—, and —CH2CH2—; R1 is selected from: —CH3 and —CF3; A is selected from: wherein, T is selected from: CH2, NH, and O; U is selected from: CH2, NH, and O; V is selected from: CH2, C═O, NH, N—CH3, and O; provided that at least one but not all of T, U, and V are CH2, and when U is O then each of T and V is other than O or N; W is selected from: CH2 and O; X is selected from: CH and N; provided that when W is CH2, X is N and when W is O, X is CH; Y is selected from: CH2, N—C6H5, and O; Z is selected from CH2 and O: R2 is selected from: H and halogen; R3 is selected from: H, cyclopropyl, and phenyl; R4 is selected from H and phenyl; wherein identifies the bond attaching A to L; and pharmaceutically acceptable salts thereof. |
