ANTHRACYCLINE PRODRUGS, METHOD FOR PREPARATION AS WELL AS THEIR USE IN SELECTIVE CHEMOTHERAPY

摘要

Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula <IMG> as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed.