Methods for reducing uric acid levels using barbiturate derivatives

摘要

Methods for reducing uric acid levels in blood or serum of a subject employing metabolites of merbarone as active agents. Methods for treating or preventing disorders of uric acid metabolism are also provided. The metabolites can be formulated as pharmaceutical compositions comprising the metabolites and a pharmaceutically acceptable carrier for use in these methods.

主权项

1. A method for reducing or preventing elevated blood or serum uric acid levels in a subject comprising administering to a subject in need thereof or a combination thereof, in an amount effective to increase renal uric acid excretion and inhibit xanthine oxidase, thereby reducing blood or serum uric acid levels.