发明名称 |
CONTROLLED RELEASE PRODUCTS |
摘要 |
A method of making a solid interpolymer for use as a controlled release matrix for a controlled release product for oral administration, involves dissolving a first polymer in a solvent therefor, dissolving one or more second complementary polymers capable of complexing with the first polymer to form the interpolymer complex, in a solvent therefor, adding a complexation inhibitor, mixing together the solutions, adjusting the pH if necessary, and spraying the product into a vessel to remove at least partially the solvents and thereby to produce solid particles of the interpolymer complex. An active agent such as a drug is preferably embedded or encapsulated in the interpolymer complex before spray drying or may be incorporated by suitable means at a later stage. |
申请公布号 |
WO9706787(A2) |
申请公布日期 |
1997.02.27 |
申请号 |
WO1996GB02016 |
申请日期 |
1996.08.16 |
申请人 |
DYER, ALISON, MARGARET;CSIR;ROLFES, HEIDI;VAN DER MERWE, THILO, LOTHAR;TRUTER, PATRICIA-ANN |
发明人 |
ROLFES, HEIDI;VAN DER MERWE, THILO, LOTHAR;TRUTER, PATRICIA-ANN |
分类号 |
A61K9/14;A61K9/20;A61K9/22 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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