| 摘要 |
The present invention is directed to a new class of 3- amido and 3-sulfamido-indolyl NMDA antagonists of the formula: (see formula Ia, Ib, Ic) wherein Z is represented by H, C1-C4 alkyl, phenyl, substituted phenyl, or an alkylphenyl sub- stituent in which the phenyl ring may be optionally substituted; R is represented by hydrogen, halogen, C1-C4 alkyl. C1-C4 alkoxy, CF3, OCF3, OH, NO2, or CN; B is represented by hydrogen, C1-C4 alkyl, op- tionally substituted alkylphenyl, or -CH2- COR2: X is represented by CO or SO2; and A and R1 are variously defined. These compounds are useful in the treatment of a number of disease states such as epilepsy, neurodegenerative dis- eases, anxiety and analgesia.
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