| 摘要 |
NEW MATERIAL:The compound of formula I (R1 and R2 are H, nitro, cyano, halogen, alkyl, alkoxy, alkylmercapto, alkylsulfoxide, etc.; R3-R5 are alkyl; R6 and R7 are alkyl, aralkyl, etc., or together with N form a heterocyclic group; X is -CO- or -COO-; A is alkylene) and its non-toxic salt. EXAMPLE:2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(4-cyano-2- pyridyl)-1,4-dihydropyridine-3,5-dicarboxylate. USE:A coronary vasodilator, cerebral blood blow increasing agent, hypotensor, preventive and remedy for thrombosis, phosphodiesterase inhibitor, etc. PREPARATION:The objective compound can be produced e.g. by reacting the compounds of formula II, III and IV in a solvent at 50-120 deg.C are reacting the resultant compound of formula V with a secondary amine.
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