发明名称 |
HETEROCYCLIC METHYL FREE RADICALS AS IMAGE ENHANCING AGENTS |
摘要 |
The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula (1) or (2), wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O)n (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or an S(O)n group; R<1> is a hydrogen atom or group of formula -M, -XM, -X-Ar<2> where M is a water solubilising group, and Ar<2> represents a 5-10 membered aromatic ring optionally substituted by a water solubilising group M; and each of the groups R<7>, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilising group M, or two groups R<7> together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally wit the ring attachment carbon replaced by a silicon atom, and R<7> where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilising group M. The novel radicals have good stability, long relaxation times and good relaxivity.
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申请公布号 |
WO9639367(A1) |
申请公布日期 |
1996.12.12 |
申请号 |
WO1995GB02151 |
申请日期 |
1995.09.08 |
申请人 |
NYCOMED IMAGING A/S;COCKBAIN, JULIAN, R., M.;ANDERSSON, SVEN;RYDBECK, ANNA;SERVIN, ROLF;WISTRAND, LARS-GORAN;RADNER, FINN |
发明人 |
ANDERSSON, SVEN;RYDBECK, ANNA;SERVIN, ROLF;WISTRAND, LARS-GORAN;RADNER, FINN |
分类号 |
C07D493/04;A61K31/58;A61K49/00;A61K49/20;C07B60/00;C07D495/04;C07D497/04;C07D497/22;C07D519/00;C07F7/08;(IPC1-7):C07B61/02 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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