| 摘要 |
Compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof are disclosed, wherein Alk is C1-6 alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen, C1-6 alkyl, nitro, hydroxy or C1-4 alkyloxy; D is an optionally substituted mono, bi- or tricyclic nitrogen containing heterocycle, a 2H-benzopyranone, a benzamide, a benzophenone or a phenoxyphenyl having central alpha 2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions. These compounds are useful for treating depression and Parkinson's disease.
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