| 摘要 |
Disclosed are heterovesicular liposomes containing different biological compositions (14, 14a) each encapsulated in sepa- rate chambers of the liposomes, having defined size distribution, adjustable internal chamber size and number, methods of mak- ing them and treatment of patients with them. The preparation process includ es the addition of composition to first lipid compo- nent in the vial to obtain an emulsion, the addition of composition to secon d lipid component in the vial to obtain a second emulsion and mixing these emulsions to form a chimeric emulsion.
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