发明名称 VERFAHREN ZUR HERSTELLUNG VON 1,4 ZU 3,6-DIANHYDRO-D-GLUCIT-2-NITRAT
摘要 The following process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate is described: acylating 1,4:3,6-dianhydro-D-glucitol with 0.5 to 1.5 molar equivalents of acetic anhydride in the presence of an acid catalyst, nitrating the product so obtained with a mixture of nitric acid and acetic anhydride, hydrolyzing the product so obtained in the presence of an inorganic base and isolating 1,4:3,6-dianhydro-D-glucitol 2-nitrate. The 1,4:3,6-dianhydro-D-glucitol 2-nitrate is useful as a coronary vasodilator.
申请公布号 DE2751934(A1) 申请公布日期 1978.08.31
申请号 DE19772751934 申请日期 1977.11.21
申请人 AMERICAN HOME PRODUCTS CORP. 发明人 HSIA CHOU,CHIH;SHARP MYERS,GORDON
分类号 C07D493/04;(IPC1-7):C07C77/02;A61K31/34;C07C76/04 主分类号 C07D493/04
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