| 发明名称 |
Process for the enzymatic preparation of GRF(1-44)NH2 |
| 摘要 |
GRF(1-44)-NH2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical pathway to the clinically important GRF(1-44)-NH2 compound.
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| 申请公布号 |
US5563044(A) |
申请公布日期 |
1996.10.08 |
| 申请号 |
US19950462453 |
申请日期 |
1995.06.05 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
FELIX, ARTHUR M.;HEIMER, EDGAR P. |
| 分类号 |
A61K31/16;A61K38/04;A61P5/00;C07K14/00;C07K14/575;C07K14/60;C12P21/02;(IPC1-7):C12P21/06;A61K37/00 |
主分类号 |
A61K31/16 |
| 代理机构 |
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代理人 |
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| 主权项 |
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