发明名称 |
STABLE FORMULATIONS |
摘要 |
The invention provides a formulation including an acetic acid buffer, a glutamic acid buffer or a succinic acid buffer with a pH from about 4.5-7.0, at least one excipient comprising a sugar or a polyol and an effective amount of a therapeutic antibody. The buffer can include a salt of acetate, glutamate or succinate and the sugar or polyol can include glycerol, sucrose, trehalose or sorbitol. The therapeutic antibody can include a human antibody, a humanized antibody, a chimeric antibody, or a functional fragment thereof. |
申请公布号 |
WO2008045373(A2) |
申请公布日期 |
2008.04.17 |
申请号 |
WO2007US21477 |
申请日期 |
2007.10.05 |
申请人 |
AMGEN INC.;MCAULEY, ARNOLD;REHDER, DOUGLAS;MATSUMURA, MASAZUMI |
发明人 |
MCAULEY, ARNOLD;REHDER, DOUGLAS;MATSUMURA, MASAZUMI |
分类号 |
A61K9/20;A61K31/44;A61K31/5377 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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