USE OF STING AGONISTS TO TREAT HEPATITIS B VIRUS INFECTION

摘要

The invention includes methods of treating a subject having hepatitis B viral (HBV) infection. In certain embodiments, the method of the invention comprises stimulating the innate cytokine response in macrophages, dendritic cells and/or liver non-parenchymal cells with small molecular STING agonists, thus suppressing HBV replication in hepatocytes. In other embodiments, the method of the invention can be used to treat chronic HBV infections. The invention further provides methods of identifying compounds useful in treating HBV infection in a subject.

主权项

1. A method of treating a subject having a hepatitis B viral (HBV) infection, the method comprising administering a pharmaceutically effective amount of a STING agonist to the subject.