| 摘要 |
The present invention is based upon the discovery that the use of pyruvate in transplant solutions and the feeding of pyruvate and/or pyruvate derivatives to the organ recipients prior to and subsequent to transplantation, greatly enhances the survivability of the recipient and the viability of the transplanted organ. According to the present invention, providing pyruvate prior to the transplantation of an organ and/or subsequent to the transplantation of the organ, will significantly increase the likelihood of a successful transplantation. Further, the use of pyruvate-containing preservation, transplant, perfusion and pyruvate irrigation solutions will greatly enhance the maintenance of the organs prior to transplantation. The transplant and irrigation solutions of the present invention contain components that are known in the art and pyruvate at a concentration from 1 to 100 mM. |
