PEPTIDES HAVING BRADYKININ ANTAGONIST ACTION

摘要

Peptides having bradykinin antagonist action Peptides of the formula I A-B-C-E-F-K-(D)-Phe-G-M-F'-I (I) in which A stands for hydrogen, alkyl, alkanoyl, alkoxy- carbonyl, alkylsulfonyl, cycloalkyl, aryl, aryloyl, arylsulfonyl, heteroaryl or an amino acid which may optionally be substituted, B is a basic amino acid, C denotes a dipeptide or tripeptide, E stands for the radical of an aromatic amino acid, F independently of one another denotes an amino acid which is optionally sub- stituted in the side chain or a direct bond, G is an amino acid, F' is as defined far F, -NH-(CH2)2-3 or may optionally denote a direct bond, T is -OH, -NH2 or -NHC2H5 and K denotes a radical -NH- (CH2)1-4 -CO- or stands for a direct bond, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.