| 摘要 |
PCT No. PCT/JP85/00392 Sec. 371 Date Feb. 24, 1986 Sec. 102(e) Date Feb. 24, 1986 PCT Filed Jul. 12, 1985 PCT Pub. No. WO86/00893 PCT Pub. Date Feb. 13, 1986.Amidine compounds of formula (I) <IMAGE> (I) and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) <IMAGE> (II) or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) <IMAGE> (III) or preferably an acid addition salt thereof. |
| 申请人 |
TORII & CO., LTD., TOKIO/TOKYO, JP |
发明人 |
FUJII, EBIYAMACHI, SETSUROU 323, KYOTO 604, JP;OKUTOME, TOSHIYUKI, TOKYO 158, JP;NAKAYAMA, NISHINARASHINO 2-CHOME, TOYOO 13-5, CHIBA 274, JP;NUNOMURA, KAWADOCHO, SHIGEKI 512-36, CHIBA 280, JP;SUDO, KIMIO, CHIBA 260, JP;WATANABE, SHINICHI, SHIGA 520, JP;KURUMI, MASATERU;AOYAMA, TAKUO, CHIBA 285, JP |
