| 发明名称 |
RAF-MEK-ERK pathway inhibitors to treat cancer |
| 摘要 |
Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bcr-Abl tyrosine kinase, imatinib.
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| 申请公布号 |
US7307071(B2) |
申请公布日期 |
2007.12.11 |
| 申请号 |
US20020308721 |
申请日期 |
2002.12.03 |
| 申请人 |
ONYX PHARMACEUTICALS, INC |
发明人 |
LYONS JOHN F.;BOLLAG GIDEON |
| 分类号 |
A61K31/025;A61K45/00;A61K31/00;A61K31/03;A61K31/075;A61K31/08;A61K31/13;A61K31/166;A61K31/17;A61K31/33;A61K31/44;A61K31/4409;A61K45/06;A61P35/00;A61P35/02 |
主分类号 |
A61K31/025 |
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