发明名称 |
Method of Designing Sirnas for Gene Silencing |
摘要 |
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
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申请公布号 |
US2008234941(A1) |
申请公布日期 |
2008.09.25 |
申请号 |
US20040577696 |
申请日期 |
2004.10.27 |
申请人 |
JACKSON AIMEE L;BARTZ STEVEN R;BURCHARD JULJA;LINSLEY PETER S;WEI GE;CAVET GUY L |
发明人 |
JACKSON AIMEE L.;BARTZ STEVEN R.;BURCHARD JULJA;LINSLEY PETER S.;WEI GE;CAVET GUY L. |
分类号 |
G01N33/48;C12N;C12N15/11;G06F19/22 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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地址 |
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