SOUCHE DE BORDETELLA DEFICIENTE DANS LA PRODUCTION DE TOXINE ET EXPRIMANT UNE PROTEINE HYDRIDE, LIPOSOMES COMPRENANT DE LA FHA ET LEURS UTILISATIONS COMME VACCINS, ET UTILISATION DE LA FHA POUR STIMULER LES REPONSES IMMUNITAIRES

摘要

The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.