Responsiveness to angiogenesis inhibitors

摘要

Disclosed is an in vitro method of determining whether a patient is suitably treated by a therapy comprising an angiogenesis inhibitor comprising bevacizumab or an antibody that binds essentially the same epitope on VEGF as bevacizumab, said method comprising: (a) determining in a sample derived from a patient suffering from cancer the genotype at polymorphism rs12505758 (SEQ ID NO. 2), and (b) identifying a patient as more or less suitably treated by a therapy with an angiogenesis inhibitor comprising bevacizumab or an antibody that binds essentially the same epitope on VEGF as bevacizumab based on said genotype, wherein the presence of each T allele at polymorphism rs12505758 (SEQ ID NO. 2) indicates an increased likelihood that said patient is more suitably treated, or the presence of each C allele at polymorphism rs12505758 (SEQ ID NO. 2) indicates an increased likelihood that said patient is less suitably treated.