| 摘要 |
PCT No. PCT/GB93/00742 Sec. 371 Date May 19, 1994 Sec. 102(e) Date May 19, 1994 PCT Filed Apr. 8, 1993 PCT Pub. No. WO93/20807 PCT Pub. Date Oct. 28, 1993Compounds of formula I, and their pharmaceutically acceptable salts, <IMAGE> in which R1 and R2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR1R2 is a heterocyclic group; A is trimethylene optionally substituted by alkyl and the phenyl ring is optionally substituted by substituents such as halogeno, alkenyl, amino, cyano, ureido, alkyl, carbamoylalkyl, alkanoylamino, alkoxycarbonyl, N-alkyl-alkanoylamino, alkanoyl and amines thereof; are inhibitors of squalene synthese and hence useful in treating diseases in which a lowering of cholesterol is desirable. As well as the use of these compounds in medicine, novel compounds, processes for their preparation and pharmaceutical compositions are also referred to.
|
