EPISOMAL EXPRESSION CASSETTES FOR GENE THERAPY

摘要

The invention consists of episomal expression cassettes for expression of a tran sgene in gene therapy. The expression cassettes consist of regulatory elements of the human cytokeratin gene and a transgene. The invention also includes liposomes for tran sfection of epithelial tissue with the cassettes in treatment of cystic fibrosis, emphyserma , cancers of epithelial origin arising in the lung or other organs.